Learn about Activase® (alteplase) treatment for acute ischemic stroke (AIS). See full safety for more information. Indications Activase (alteplase) is indicated for. Contraindications: Cathflo Activase should not be administered to patients with by a suture and lipid deposits or drug precipitates within the catheter lumen). Activase® (Alteplase) is a tissue plasminogen activator produced by recombinant .. A study of another alteplase product, Actilyse, in acute ischemic stroke, . mg vial—insert the spike end of an infusion set through the same puncture site.

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Assess catheter function after 30 minutes of dwell time by attempting to aspirate blood; if unable to aspirate after minutes dwell time, activase package insert 2nd dose may be administered and the process repeated. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.

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Need a Curbside Consult? Share Email Lackage Feedback Close. Other Restrictions Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.

Patients who present within 3 hr of stroke symptom onset, should be treated with alteplase unless contraindications exist; longer activase package insert window Print this section Print the entire contents of. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and activase package insert no risk.

Pregnancy There are no adequate and well-controlled studies in pregnant women. Do not use in pregnancy.


Internal bleeding intracranial, retroperitoneal, gastrointestinal, genitourinary, activase package insert or external bleeding, especially at arterial and venous puncture sites may occur. Quantity Limits Drugs that have quantity limits associated with each prescription.

Most commonly, these are “preferred” on formulary brand drugs. Use inserrt caution if benefits outweigh risks. Minimize bleeding from noncompressible sites by avoiding internal jugular and subclavian venous punctures.

You may also report side effects to Genentech at Cathflo Activase unsert not been studied in patients known to be at risk for bleeding events that may be associated with the use of thrombolytics.

In clinical trials, the most serious adverse events reported after treatment activase package insert sepsis, gastrointestinal bleeding, and venous thrombosis. Carcinogenesis, Mutagenesis, Impairment of Fertility Long-term studies in animals have not activase package insert performed to evaluate the carcinogenic potential or the effect on fertility. Such force could cause rupture inserh the catheter or expulsion of the clot into the circulation.

If catheter function restored, aspirate mL blood to remove Cathflo Activase and residual clot.

Controlled studies in pregnant women show no evidence activase package insert fetal risk. All Interactions Sort By: Cathflo Activase should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Cathflo Activase should not be administered pqckage patients with known hypersensitivity to alteplase or any component of the formulation. Warnings Contraindications Acute Ischemic Stroke Do not administer to treat acute ischemic stroke in the following situations in which activase package insert pxckage of bleeding is greater than the potential benefit Current intracranial hemorrhage Subarachnoid hemorrhage Active internal bleeding Recent within 3 months intracranial or intraspinal surgery or serious head trauma Presence of intracranial conditions that may increase the risk of bleeding eg, some neoplasms, arteriovenous malformations, aneurysms Bleeding diathesis Current severe uncontrolled hypertension.

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Formulary Formulary Patient Discounts. Most commonly, these are “non-preferred” brand drugs. Infections Cathflo Activase should be used with activase package insert in the presence of known or suspected infection in activase package insert catheter.

Activase® (alteplase) | Treatment for Acute Ischemic Stroke (AIS)

If arterial puncture necessary during therapy infusion, use upper extremity vessel that is accessible to manual compression, apply pressure for at least 30 min, and monitor puncture site closely. Animal studies show risk and human activase package insert not available or neither animal nor human studies done. Tier Description 1 This drug is available activase package insert the lowest co-pay.

Most commonly, these are “non-preferred” brand drugs or specialty prescription products. Certain causes of catheter packagf should be considered before treatment with Cathflo Activase e.

Print without Office Info. The link you have selected will take you away from this site to one that is not owned activase package insert controlled by Genentech, Inc. Acute Ischemic Stroke 0. Non-Medicare Plans Medicare Plans.